Long COVID is Underdiagnosed Autoimmune Autonomic Ganglionopathy
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Long COVID is Underdiagnosed Autoimmune Autonomic Ganglionopathy
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Autoimmune Autonomic Ganglionopathy (AAG): Understanding Long COVID

Diagram showing autonomic dysfunction causing symptoms in muscle, brain, body functions, and hemodynamics.

GET YOUR LIFE BACK FROM LONG COVID

WHAT IS Autoimmune Autonomic Ganglionopathy (AAG)? (Simplified Explanation) In Simple Terms: Your autonomic nervous system controls everything automatic: Heart rate & blood pressure, Digestion & stomach emptying, Temperature regulation, Thinking & memory, Immune responses, Sexual function. Ganglionic antibodies block the receptors that transmit signals in your autonomic nervous system. Result: Everything controlled by your autonomic nervous system stops working properly. ONE Mechanism → 200+ Symptoms. Not 200 different problems. One broken system affecting everything it controls. TREATMENT EXISTS This Is NOT Untreatable: ✅ AAG treatment is available: Test exists for ganglionic antibodies (Mayo/ARUP/Quest, ~$500) ✅ Treatment exists: IVIG/plasmapheresis (FDA-approved for AAG) ✅ Evidence exists: 83.5% improvement in established AAG ✅ Population validation: 58% benefit in 3,925 Long COVID patients experiencing symptoms. What's Missing? RECOGNITION. That's Why This Website Exists.

[Treatment Roadmap by Phenotype →]
TEST THE ANTIBODY

TEST THE ANTIBODY

085902: Acetylcholine Receptor (AChR)-binding Antibodies | Labcorp. Understanding the role of AChR-binding antibodies is crucial, especially in the context of AAG treatment, which can significantly impact the autonomic nervous system. Additionally, these antibodies may be relevant for addressing Long COVID symptoms, as they can affect various neurological functions.

A woman in a white robe receiving IV therapy while holding a glass of water with lemon.

TREAT THE DISEASE

IVIG (Intravenous Immunoglobulin) is a vital treatment option for various conditions, including AAG treatment. This therapy can also play a role in addressing issues related to the autonomic nervous system, particularly in patients experiencing Long COVID symptoms.

   

 

The evidence is here. The mechanism is plausible. The treatment is available.

TEST THE ANTIBODY. TREAT THE DISEASE. SAVE THE LIVES.

Content on this site is for informational and advocacy purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult qualified healthcare professionals. 

  

The Palladino Theory: Autoimmune Autonomic Ganglionopathy as a Unifying Mechanism for Long COVID Symptom Heterogeneity and Universal Treatment Failure - Publish Date: 12/15/25

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